07-06-2020 Council Work Session Packet

Home Search

This document is the Intellectual Property of SGS AXYS Analytical Services Ltd. and contains Proprietary and Confidential Business Information. It may not be reproduced or distributed without written permission of the owner. © SGS AXYS Analytical Services Ltd, 2020. SGS AXYS Analytical Services Ltd, 2045 Mills Road W., Sidney, BC, Canada, V8L 5X2. Tel. (250) 655-5800, fax (250) 655-5811. This is not a controlled document; it is subject to change without notification. SGS AXYS Analytical Services Ltd. MSU-110 Rev 14, 28-May-2020 Summary of MLA-110 Rev 02 Ver 07 Page 16 of 23 SGS AXYS confidential, not to be distributed without written permission 2 These surrogates used only to quantify the analogous native compounds. Formal surrogate recovery limits are under review. 3 For DoD: Surrogate recoveries are determined by comparing surrogate peak area in samples to surrogate’s area measured in the day’s initial cal/ver (or I-CAL if run that day). QC Specification Table: Other Parameters QC Parameter Specification MS Acquisition Rate Minimum acquisition rate for every native analyte and labeled compound peak: At least 10 data points per peak. Instrument Sensitivity Daily, S:N ≥ 10:1 for the primary transition product ion for all analytes for the lowest calibration standard (CAL B) and S:N ≥ 3:1 for the secondary ion. Additional requirement for DoD: Prior to sample analysis and then at least once every 12 hours, verify sensitivity at the LOQ level by running CAL C The found analyte concentrations must be within ±30% of the true values. Mass Calibration Instrument must have a valid mass calibration following the manufacturer specified procedure prior to any sample analysis. The mass calibration is updated on an as-needed basis (e.g. QC failures, ion masses fall outside of the ±0.5 amu of the true value, major instrument maintenance, or if the instrument is moved.) Refer to SIN-033. The entire range (bracketing all the masses of the target analytes) must be mass calibrated. The maximal allowed residual error is ≤ 0.1 Da for each mode with no more than two calibration points missed. Mass Calibration Verification Mass calibration is verified after each mass calibration, prior to initial ICAL. Mass calibration must be verified to be ±0.5 amu of true value by acquiring a full scan continuum mass spectrum of a PFAS stock standard OR by following the instrument manufacturer’s instructions for performing a mass calibration verification and using the instrument manufacturer’s recommended standards as long as these standards cover the mass range of the PFAS ions of interest. Initial Calibration (I-CAL) Run initially, and as required to maintain calibration verification and instrument sensitivity. CAL A is a sensitivity standard S:N ≥ 3:1 for the primary transition product ion for all analytes. CAL B is the default lowest calibration standard. (CAL A is not included in determination of the RRF). Quantification is achieved by the constant RRF method. The I-CAL specifications for the RRF fit are <20% RSD of mean RRFs and 70-130 % recovery of analytes at each concentration level down to C level. The recovery specification for the B CAL is 50-200%. The surrogate recovery specifications are 50-150% recovery at each concentration level. Peak Asymmetry: 0.8-1.5 for PFBA and PFPeA measured in CAL E (mid cal point) at 10% of the peak height. If this is not achieved, perform instrument maintenance and re-run I-CAL. www.axysanalytical.com Page 21 of 94